Population Genetics, a textbook designed for advanced undergraduate and graduate students, aims to make population genetics approachable, logical, and easily understood. The book's design emphasizes introductions to key principles and predictions in the field augmented with case studies as illustrations.

The book includes novel pedagogical features such as "interact" boxes that guide readers step-by-step through computer simulations using public domain software, "math" boxes that fully explain mathematical derivations, and "problem" boxes integrated into the text to reinforce concepts as they are encountered. The text also offers a highly accessible introduction to coalescent theory, the major conceptual advance in population genetics of the past two decades.